RuneCrafting is one of the hardest skills in RuneScape and is the most repetive skill in the game. Rune Mysteries quest has to be completed in order to start RuneCrafting. Most people do not get all the way to 99 in one go, though it is recommended to do so. Do not think that if you no life it you will be able to do it all in 1 week or so, no, even if you no life it, it will still take over a month.
This Guide is very basic for all the ones that have never had experience with Runecrafting before.